St. Peter's Wort Toxic?

Updated 2026-03-06| 3 min read| 2,379 found this helpful
Hypericum tetrapterum Fr. (syn. Hypericum acutum Moench)
1

The entire plant is toxic, with highest concentrations in flowers and leaves; ~20% of toxicity remains in dried fodder.

2

Horses are uniquely sensitive to its toxins, with severe reactions including coma possible if left untreated.

3

Core toxic effects include UV-triggered skin lesions on unpigmented skin, plus appetite loss and neurological symptoms.

FAQ

Is St. Peter's Wort toxic to Humans?

No specific human toxicity data documented; large ingestion may cause mild photosensitivity and gastrointestinal upset as a general Hypericum risk. (Low)

Is St. Peter's Wort toxic to Cats?

No confirmed feline toxicity cases reported in this dataset; monitor for photosensitivity, lethargy and appetite loss if ingested. (Low)

Is St. Peter's Wort toxic to Dogs?

No confirmed canine toxicity cases reported in this dataset; monitor for photosensitivity, gastrointestinal distress and restlessness if ingested. (Low)

Is St. Peter's Wort toxic to Horses?

Lesions (redness, edema, black crusts) on sun-exposed unpigmented skin prone to secondary infection, appetite loss, unsteadiness, seizures, coma in severe cases. (Moderate)

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Toxicity Details

Humans
Low

No specific human toxicity data documented; large ingestion may cause mild photosensitivity and gastrointestinal upset as a general Hypericum risk.

Cats
Low

No confirmed feline toxicity cases reported in this dataset; monitor for photosensitivity, lethargy and appetite loss if ingested.

Dogs
Low

No confirmed canine toxicity cases reported in this dataset; monitor for photosensitivity, gastrointestinal distress and restlessness if ingested.

Horses
Moderate

Lesions (redness, edema, black crusts) on sun-exposed unpigmented skin prone to secondary infection, appetite loss, unsteadiness, seizures, coma in severe cases.

Toxicity Snapshot

Toxic PartsEntire plant, with highest toxin levels in flowers and leaves; toxicity varies widely between individual specimens.
Exposure RouteIngestion is the primary confirmed exposure route; skin contact may trigger mild photosensitivity reactions in sensitive individuals.
Toxic CompoundsHypericin; Pseudohypericin; Flavonoids (including Hyperoside); Essential oils; Tannins; Antibiotically active compounds; Phenolic acids

First Aid & Prevention

First 30 Minutes

  • • Move exposed animal immediately out of direct sunlight into a fully shaded area or enclosed stall.
  • • Remove all remaining plant material from the animal's mouth and environment to stop further ingestion.
  • • Rinse sun-exposed unpigmented skin areas with cool clean water to reduce initial irritation.

Contact Vet Immediately

  • • Visible skin lesions (redness, swelling, black crusts) appear on unpigmented skin areas.
  • • The animal exhibits appetite loss, restlessness, unsteadiness, or seizures.
  • • The exposed animal is a horse, as they are uniquely sensitive to this plant's toxins.

Prevention

  • • Inspect pastures and hay supplies for Hypericum tetrapterum growth before turning out grazing livestock.
  • • Avoid feeding dried fodder contaminated with this plant, as ~20% of its toxicity is retained after drying.
  • • Keep small companion animals away from ornamental plantings of this or related Hypericum species.

Treatment & Prognosis

  • • Administer decontamination and symptomatic care per standard veterinary toxicology emergency protocols.
  • • Use local or parenteral antibiotics paired with glucocorticoids to treat skin lesions and reduce inflammation.
  • • Administer zinc-cod liver oil paste and niacin to support skin tissue recovery.
  • • Note that antihistamines have low efficacy for treating toxicity from this plant.
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Professional Toxicology

Scientific NameHypericum tetrapterum Fr. (syn. Hypericum acutum Moench)
AliasesPeterwort、Square Stemmed St. John's wort、Square Stalked St. John's wort
Toxicity Grade
HumansLow
CatsLow
DogsLow
HorsesModerate
Target Organs
SkinGastrointestinal tractCentral nervous system
Mechanism of Action

• Hypericin and related compounds react to UV radiation, triggering oxidative damage to unpigmented skin tissue (photosensitivity).

• Systemic absorption of toxic compounds causes gastrointestinal distress and neurological impairment in sensitive species.

Other Species Risk (CliniTox)

Information from CliniTox veterinary text.

Cattle: Confirmed poisoning cases reported, presenting with photosensitive dermatitis and appetite loss
Sheep: Confirmed poisoning cases reported, with photosensitivity reactions after grazing contaminated pasture
Pigs: Confirmed poisoning cases reported, with skin lesions and systemic symptoms following ingestion
Confusion Risk

The following plants look similar and may be confused:

Other St. John's Wort species Hypericum spp.
Visually similar to other Hypericum variants; most share comparable photosensitizing toxicity profiles, varying only in potency.
Groundsel/Ragwort species Senecio spp.
May be mistaken for Hypericum during vegetative growth stages; Senecio species are far more toxic, causing irreversible liver damage.
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Data Sources

This information is for reference only and does not constitute medical advice. If ingestion or poisoning is suspected, seek medical or veterinary attention immediately.

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