Tall yellow sweetclover Toxic?

Updated 2026-03-06| 5 min read| 2,857 found this helpful
Melilotus altissimus Thuill.
1

Only mold-infested plant material is toxic, as mold produces the dangerous primary toxin dicumarol

2

Toxic exposure causes sweet clover disease marked by uncontrolled bleeding, anemia, and potential organ damage

3

Vitamin K1 is the specific, effective antidote for confirmed dicumarol poisoning from this plant

FAQ

Is Tall yellow sweetclover toxic to Humans?

No specific human toxicity data is documented, but ingestion of large amounts of mold-infested material may carry bleeding risk (Low)

Is Tall yellow sweetclover toxic to Cats?

No species-specific toxicity reports exist, but ingestion of moldy material may cause lethargy, unusual bleeding, or anemia (Low)

Is Tall yellow sweetclover toxic to Dogs?

No species-specific toxicity reports exist, but ingestion of moldy material may cause lethargy, spontaneous bleeding, or anemia (Low)

Is Tall yellow sweetclover toxic to Horses?

Weakness, pale mucous membranes, anemia, spontaneous bleeding (nose, urine, feces, vagina), abortion, subcutaneous hematomas, joint swelling/lameness, neurological signs, rapid breathing, and potential fatal hemorrhage (High)

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Toxicity Details

Humans
Low

No specific human toxicity data is documented, but ingestion of large amounts of mold-infested material may carry bleeding risk

Cats
Low

No species-specific toxicity reports exist, but ingestion of moldy material may cause lethargy, unusual bleeding, or anemia

Dogs
Low

No species-specific toxicity reports exist, but ingestion of moldy material may cause lethargy, spontaneous bleeding, or anemia

Horses
High

Weakness, pale mucous membranes, anemia, spontaneous bleeding (nose, urine, feces, vagina), abortion, subcutaneous hematomas, joint swelling/lameness, neurological signs, rapid breathing, and potential fatal hemorrhage

Toxicity Snapshot

Toxic PartsWhole plant, only when colonized by mold
Exposure RouteIngestion of mold-contaminated fresh plant, hay, or forage
Toxic CompoundsCoumarin (0.3-0.9%); 3,4-Dihydrocoumarin (Melilotin); o-Dihydrocoumaric acid (Melilotic acid); Hydroxycoumarins; Dicumarol (3,3'-Methylene-bis-4-hydroxycoumarin)

First Aid & Prevention

First 30 Minutes

  • • Immediately remove all access to suspected mold-infested sweet clover forage or hay
  • • Induce vomiting in small animals if recent ingestion of large amounts of moldy plant material is observed, only if advised by a vet
  • • Monitor for signs of unusual bleeding, lethargy, or uncoordinated movement while awaiting veterinary care

Contact Vet Immediately

  • • Any observed signs of spontaneous bleeding (nose bleeds, blood in urine/feces, unexplained bruising)
  • • Suspected ingestion of large quantities of mold-infested tall yellow sweetclover
  • • Presence of anemia, lethargy, lameness, abortion, or neurological changes in animals with access to sweet clover forage

Prevention

  • • Inspect all hay and forage supplies for visible mold before feeding to livestock or allowing pet access
  • • Harvest sweet clover for forage only in dry conditions, and cure hay fully to prevent mold growth
  • • Discard any batches of sweet clover hay that show visible mold or musty odors

Treatment & Prognosis

  • • Administer Vitamin K1 as the specific antidote per veterinary dosing instructions
  • • Perform whole blood transfusion from a healthy donor animal for cases of severe, life-threatening bleeding or anemia
  • • Provide supportive care including rest, oxygen therapy for hypoxic animals, and restricted activity to avoid trauma-related bleeding
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Professional Toxicology

Scientific NameMelilotus altissimus Thuill.
AliasesTall melilot、High sweetclover
Toxicity Grade
HumansLow
CatsLow
DogsLow
HorsesHigh
Target Organs
Circulatory systemLiverReproductive systemJoints and musculoskeletal systemBrainPericardium and body serous cavities
Mechanism of Action

• Aspergillus or Penicillium mold colonizing the plant converts naturally occurring coumarin glycosides into the toxic compound dicumarol

• Dicumarol inhibits synthesis of vitamin K-dependent blood clotting factors, impairing normal coagulation

• Prolonged exposure leads to widespread spontaneous bleeding, tissue hypoxia, and organ damage as toxicity progresses

Other Species Risk (CliniTox)

Information from CliniTox veterinary text.

Cattle: High risk, develops classic sweet clover disease including spontaneous bleeding, abortion, bleeding from newborn calf navels, joint hematomas, and fatal hemorrhages
Sheep: Moderate risk, develops similar bleeding and anemia symptoms as cattle after consuming mold-contaminated sweet clover forage
Goats: Moderate risk, susceptible to dicumarol poisoning from mold-infested material, presenting with spontaneous bleeding and anemia
Confusion Risk

The following plants look similar and may be confused:

Other sweetclover species Melilotus spp.
Visually identical in growth form, yellow flower appearance, and habitat; all Melilotus species contain coumarin and carry the same mold-related toxicity risk
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Data Sources

This information is for reference only and does not constitute medical advice. If ingestion or poisoning is suspected, seek medical or veterinary attention immediately.

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