Alexandrian senna Toxic?

Updated 2026-03-06| 3 min read| 1,484 found this helpful
Cassia senna L., Cassia acutifolia Delile, Senna alexandrina Mill.
1

All plant parts are toxic, with seeds containing the highest concentration of harmful compounds

2

Toxicity is primarily driven by anthracene derivatives including multiple sennoside variants, plus naphthalene derivatives

3

Exposure causes muscle degeneration, diarrhea, ataxia and potentially life-threatening organ damage in livestock and other animals

FAQ

Is Alexandrian senna toxic to Humans?

Symptoms not formally documented in available data; large exposures may cause abdominal cramping, diarrhea, muscle weakness and electrolyte imbalance (Moderate)

Is Alexandrian senna toxic to Cats?

No specific toxicity symptoms recorded for cats in available clinical data (Unknown)

Is Alexandrian senna toxic to Dogs?

No specific toxicity symptoms recorded for dogs in available clinical data (Unknown)

Is Alexandrian senna toxic to Horses?

Weight loss, muscle weakness, ataxia, diarrhea, recumbency, myoglobinuria, heart and skeletal muscle degeneration (Moderate)

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Toxicity Details

Humans
Moderate

Symptoms not formally documented in available data; large exposures may cause abdominal cramping, diarrhea, muscle weakness and electrolyte imbalance

Cats
Unknown

No specific toxicity symptoms recorded for cats in available clinical data

Dogs
Unknown

No specific toxicity symptoms recorded for dogs in available clinical data

Horses
Moderate

Weight loss, muscle weakness, ataxia, diarrhea, recumbency, myoglobinuria, heart and skeletal muscle degeneration

Toxicity Snapshot

Toxic PartsEntire plant, especially the seeds
Exposure RouteIngestion is the primary exposure route, from accidental consumption of wild plant material or improper use of senna-containing herbal products
Toxic CompoundsSennoside A; Sennoside A1; Sennoside B; Sennidin; Sennoside C; Sennoside D; Sennoside D1; Sennoside E; Sennoside F; 6-Hydroxymusizin glucoside; Tinnevellin glucoside; Cassiaphenone glucosides; Cassiaxanthone

First Aid & Prevention

First 30 Minutes

  • • Induce vomiting only if ingestion occurred within 2 hours and the exposed subject is fully conscious with no seizure activity
  • • Administer activated charcoal to bind unabsorbed toxic compounds in the gastrointestinal tract
  • • Remove all remaining plant material from the exposure site to prevent further consumption

Contact Vet Immediately

  • • If ingestion is confirmed in horses, livestock or companion animals
  • • If symptoms including diarrhea, muscle weakness, ataxia or disorientation appear after exposure
  • • If large quantities of the plant have been ingested by any species

Prevention

  • • Clear livestock grazing areas and pet access zones of Alexandrian senna growth
  • • Store senna-containing herbal supplements securely out of reach of children and animals
  • • Confirm plant identity with a botanical expert before using any wild plants for forage or medicinal purposes

Treatment & Prognosis

  • • Perform gastrointestinal decontamination appropriate for the exposure timeline and affected species
  • • Deliver supportive care including fluid therapy, electrolyte correction and cardiac function monitoring
  • • Manage secondary complications such as myoglobinuria-related kidney damage and muscle degeneration as needed
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Professional Toxicology

Scientific NameCassia senna L., Cassia acutifolia Delile, Senna alexandrina Mill.
AliasesKhartoum senna、Alexandrine senna
Toxicity Grade
HumansModerate
CatsUnknown
DogsUnknown
HorsesModerate
Target Organs
Gastrointestinal tractSkeletal muscleCardiac muscleKidneys
Mechanism of Action

• Anthracene derivatives like sennosides irritate the gastrointestinal tract lining, causing diarrhea and electrolyte loss

• Toxic compounds directly damage cardiac and skeletal muscle tissue, leading to muscle degeneration

• Rhabdomyolysis releases myoglobin into the bloodstream, which can cause acute kidney injury

Other Species Risk (CliniTox)

Information from CliniTox veterinary text.

Cattle: May develop weight loss, muscle weakness, diarrhea, muscle degeneration and organ damage after ingestion
Goats: Susceptible to toxic effects including gastrointestinal distress, muscle damage and coordination loss
Sheep: May experience diarrhea, recumbency, muscle degeneration and cardiac complications post-exposure
Pigs: Susceptible to sennoside toxicity, with symptoms including gastrointestinal irritation and muscle weakness
Rabbits: Ingestion can lead to diarrhea, weight loss and potential organ damage
Chickens: Vulnerable to toxic effects from consumption of any part of the plant
Confusion Risk

The following plants look similar and may be confused:

Other Cassia species Cassia spp.
Most other Cassia species are also toxic; they share similar leaf and growth morphology, and can be differentiated by differences in flower and seed pod structure
Golden chain Laburnum anagyroides
Both are leguminous plants with yellow flowers; golden chain has long, hanging clusters of pea-like flowers that are not present on Alexandrian senna, and is also highly toxic
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Data Sources

This information is for reference only and does not constitute medical advice. If ingestion or poisoning is suspected, seek medical or veterinary attention immediately.

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